Transmission of human immunodeficiency virus type 1 nevirapine resistance mutation K103N from a treatment-naive mother to her child

Pediatr Infect Dis J. 2006 Mar;25(3):275-6. doi: 10.1097/01.inf.0000202142.34502.5e.

Abstract

Vertical infection of drug-resistant human immunodeficiency virus type 1 (HIV-1) has occasionally been reported in children from pretreated mothers with HIV-1 infection. In this report, a treatment-naive mother transmitted HIV-1 resistance mutation K103N against nevirapine to her child.

Publication types

  • Case Reports

MeSH terms

  • Anti-HIV Agents / pharmacology*
  • Drug Resistance, Viral* / genetics
  • Fatal Outcome
  • Female
  • HIV Infections / drug therapy
  • HIV Infections / transmission*
  • HIV Infections / virology
  • HIV-1 / classification
  • HIV-1 / drug effects*
  • HIV-1 / genetics
  • Humans
  • Infant, Newborn
  • Infectious Disease Transmission, Vertical*
  • Male
  • Mutation
  • Nevirapine / pharmacology*
  • Pregnancy
  • Pregnancy Complications, Infectious / virology
  • Reverse Transcriptase Inhibitors / pharmacology*

Substances

  • Anti-HIV Agents
  • Reverse Transcriptase Inhibitors
  • Nevirapine