Expanding the substrate scope for C-H amination reactions: oxidative cyclization of urea and guanidine derivatives

Org Lett. 2006 Mar 16;8(6):1073-6. doi: 10.1021/ol052920y.

Abstract

[reaction: see text] Oxidative C-H amination of N-trichloroethoxysulfonyl-protected ureas and guanidines is demonstrated to proceed in high yield for tertiary and benzylic-derived substrates. The success of these reactions is predicated on the choice of the electron-withdrawn 2,2,2-trichloroethoxysulfonyl (Tces) protecting group, the commercial catalyst Rh(2)(esp)(2) (1-2 mol %), and toluene as solvent. The frequency with which the heterocyclic imidazolidin-2-ones and 2-aminoimidazolines appear as structural elements in both natural products and therapeutically designed molecules confers these methods with a large number of potential applications.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amination
  • Catalysis
  • Cyclization
  • Guanidines / chemistry*
  • Molecular Structure
  • Oxidation-Reduction
  • Urea / analogs & derivatives*
  • Urea / chemistry*

Substances

  • Guanidines
  • Urea