Abstract
[reaction: see text] A phytochemical study of the secondary metabolites produced by the species of Isodon rubescens has led to the isolation of three new dimeric ent-kauranoids and two known ones. The most important of these compounds are bisrubescensin A (1), which contains an unprecedented C(23) ent-kaurane unit, and bisrubescensin C (3), which is the precursor of bisrubescensin B (2) from the viewpoint of biosynthesis. Their structures were determined on the basis of extensive spectroscopic analysis and chemical evidence.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic* / chemistry
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Antineoplastic Agents, Phytogenic* / isolation & purification
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Antineoplastic Agents, Phytogenic* / pharmacology
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Diterpenes, Kaurane* / chemistry
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Diterpenes, Kaurane* / isolation & purification
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Diterpenes, Kaurane* / pharmacology
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Drug Screening Assays, Antitumor
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Humans
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Isodon / chemistry*
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Molecular Structure
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Plants, Medicinal / chemistry*
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents, Phytogenic
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Diterpenes, Kaurane
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bisrubescensin A
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bisrubescensin B
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bisrubescensin C