Development of a concise and diversity-oriented approach for the synthesis of plecomacrolides via the diene-ene RCM

Kui Lu; Mengwei Huang; Zheng Xiang; Yongxiang Liu; Jiahua Chen; Zhen Yang

doi:10.1021/ol060221v

Development of a concise and diversity-oriented approach for the synthesis of plecomacrolides via the diene-ene RCM

Org Lett. 2006 Mar 16;8(6):1193-6. doi: 10.1021/ol060221v.

Authors

Kui Lu¹, Mengwei Huang, Zheng Xiang, Yongxiang Liu, Jiahua Chen, Zhen Yang

Affiliation

¹ Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Beijing, China.

PMID: 16524301
DOI: 10.1021/ol060221v

Abstract

[reaction: see text] A concise synthesis of the core structures of plecomacrolide with ring sizes varying from 16 to 19 atoms was achieved for the first time by the diene-ene ring-closing olefin metathesis reaction. This approach should allow access to the structurally diverse analogues of plecomacrolide.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biological Products / chemical synthesis*
Biological Products / chemistry
Catalysis
Cyclization
Macrolides / chemical synthesis*
Macrolides / chemistry
Molecular Structure

Substances

Biological Products
Macrolides
hygrolidin
concanamycin A
bafilomycin A1