Abstract
The authors report nine patients with systemic lupus erythematosus associated with anti-topoisomerase I antibodies (ELISA test) without features of systemic sclerosis. These antibodies were correlated with the disease activity and might be a marker of the severity of the closely related to difusse proliferative glomerulonephritis.
MeSH terms
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Adult
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Antibodies, Monoclonal / blood*
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Biomarkers / blood
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DNA Topoisomerases, Type I / immunology*
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Female
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Follow-Up Studies
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Glomerulonephritis / blood
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Glomerulonephritis / diagnosis*
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Glomerulonephritis / immunology*
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Humans
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Lupus Erythematosus, Systemic / blood
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Lupus Erythematosus, Systemic / complications
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Lupus Erythematosus, Systemic / immunology*
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Male
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Predictive Value of Tests
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Prognosis
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Severity of Illness Index*
Substances
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Antibodies, Monoclonal
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Biomarkers
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DNA Topoisomerases, Type I