[The detection of rotavirus RNA in nasopharyngeal smears by molecular hybridization]

Zh Mikrobiol Epidemiol Immunobiol. 1991 Apr:(4):23-5.
[Article in Russian]

Abstract

Rotavirus RNA was detected in nasopharyngeal washings, obtained from patients with rotavirus gastroenteritis (76.3% of cases) and gastroenteritis of unknown etiology (34.7% of cases), by the method of molecular hybridization with the use of RNA of monkey virus SA11, labeled with 32P in the process of T4-ligase reaction. In 100% of cases this detection correlated with the presence of lesions of the upper respiratory ways and was probably indicative of the rotavirus nature of the catarrhal syndrome in rotavirus gastroenteritis.

Publication types

  • English Abstract

MeSH terms

  • Acute Disease
  • Child
  • Child, Preschool
  • Electrophoresis, Polyacrylamide Gel
  • Feces / microbiology
  • Gastroenteritis / microbiology
  • Humans
  • Infant
  • Nasopharynx / microbiology*
  • Nucleic Acid Hybridization* / genetics
  • RNA Probes
  • RNA, Viral / genetics
  • RNA, Viral / isolation & purification*
  • Respiratory Tract Infections / microbiology
  • Rotavirus / genetics
  • Rotavirus / isolation & purification*

Substances

  • RNA Probes
  • RNA, Viral