Abstract
After implantation in the exposed pulp, some molecules of the den-tin extracellular matrix induce the formation of a reparative dentinal bridge in the coronal pulp. In some cases, total occlusion of the root canal also is observed. This is the case for bone sialoprotein, bone morphogenetic protein-7, Dentonin (a fragment from matrix extracellular phosphoglycoprotein), and two small amelogenin gene splice products (A+4 and A-4). Cells implicated in the reparative process are recruited, proliferate, and differentiate into osteoblast-like and odontoblast-like cells. The same results may be obtained by direct implantation of odontoblast progenitor cell into the pulp.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Biocompatible Materials / metabolism
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Biocompatible Materials / therapeutic use*
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Bone Morphogenetic Proteins / metabolism
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Bone Morphogenetic Proteins / therapeutic use
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Calcium Hydroxide / therapeutic use
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Dental Pulp Capping / methods*
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Dental Restoration, Permanent / methods*
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Dentin / cytology
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Dentin / metabolism*
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Dentin / surgery
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Extracellular Matrix Proteins / metabolism
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Extracellular Matrix Proteins / therapeutic use*
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Glycoproteins / metabolism
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Glycoproteins / therapeutic use
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Humans
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Integrin-Binding Sialoprotein
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Phosphoproteins / metabolism
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Phosphoproteins / therapeutic use
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Rats
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Sialoglycoproteins / metabolism
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Sialoglycoproteins / therapeutic use
Substances
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Biocompatible Materials
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Bone Morphogenetic Proteins
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Extracellular Matrix Proteins
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Glycoproteins
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IBSP protein, human
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Integrin-Binding Sialoprotein
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MEPE protein, human
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Phosphoproteins
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Sialoglycoproteins
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Calcium Hydroxide