Abstract
The surface of the intestinal mucosa is constantly assaulted by food antigens and enormous numbers of commensal microbes and their products, which are sampled by dendritic cells (DCs). Recent work shows that the mesenteric lymph nodes (MLNs) are the key site for tolerance induction to food proteins and that they also act as a firewall to prevent live commensal intestinal bacteria from penetrating the systemic immune system.
Publication types
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Comment
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Oral
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Animals
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Antigens / administration & dosage
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Antigens / immunology
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Autoimmune Diseases / immunology
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Autoimmune Diseases / therapy
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Cell Movement / genetics
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Cell Movement / immunology*
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Dendritic Cells / immunology*
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Immune Tolerance / immunology*
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Immunity, Mucosal*
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Intestine, Small / anatomy & histology
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Intestine, Small / immunology
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Intestine, Small / transplantation
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Lymph Nodes / anatomy & histology
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Lymph Nodes / immunology*
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Mesentery / immunology*
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Mice
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Mice, Inbred BALB C
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Mice, Knockout
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Receptors, CCR7
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Receptors, Chemokine / deficiency
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Receptors, Chemokine / immunology*
Substances
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Antigens
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Ccr7 protein, mouse
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Receptors, CCR7
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Receptors, Chemokine