Treatment of unresectable malignant rhabdoid tumor of the orbit with tandem high-dose chemotherapy and gamma-knife radiosurgery

Pediatr Blood Cancer. 2006 Nov;47(6):846-50. doi: 10.1002/pbc.20699.

Abstract

Malignant rhabdoid tumor (MRT) is a rare and highly aggressive tumor that primarily occurs in very young children. We report here a patient with a primary MRT of the orbit who received tandem high-dose chemotherapy and gamma-knife radiosurgery. Although the tumor was not completely removed, and the initial chemotherapy failed, the patient achieved long-term survival after this modality of treatment. This approach may be one to be further considered in patients with MRT.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Combined Modality Therapy
  • Dose-Response Relationship, Drug
  • Humans
  • Immunohistochemistry
  • Infant
  • Magnetic Resonance Imaging
  • Male
  • Orbital Neoplasms / diagnosis
  • Orbital Neoplasms / pathology
  • Orbital Neoplasms / therapy*
  • Predictive Value of Tests
  • Prognosis
  • Radiosurgery*
  • Rhabdoid Tumor / diagnosis
  • Rhabdoid Tumor / pathology
  • Rhabdoid Tumor / therapy*
  • Treatment Outcome