Blockage of PI3K/PKB/P27kip1 signaling pathway can antagonize 17 beta-estradiol-induced Ishikawa proliferation and cell cycle progression

Chin Med J (Engl). 2006 Feb 5;119(3):242-5.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apoptosis / drug effects
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Chromones / pharmacology
  • Cyclin-Dependent Kinase Inhibitor p27 / antagonists & inhibitors*
  • Cyclin-Dependent Kinase Inhibitor p27 / physiology
  • Endometrial Neoplasms / drug therapy*
  • Endometrial Neoplasms / pathology
  • Estradiol / pharmacology*
  • Female
  • G1 Phase / drug effects
  • Humans
  • Intracellular Signaling Peptides and Proteins / antagonists & inhibitors*
  • Intracellular Signaling Peptides and Proteins / physiology
  • Morpholines / pharmacology
  • Phosphatidylinositol 3-Kinases / physiology
  • Phosphoinositide-3 Kinase Inhibitors*
  • Proto-Oncogene Proteins c-akt / antagonists & inhibitors*
  • Proto-Oncogene Proteins c-akt / physiology
  • Signal Transduction / drug effects*
  • Signal Transduction / physiology

Substances

  • CDKN1B protein, human
  • Chromones
  • Intracellular Signaling Peptides and Proteins
  • Morpholines
  • Phosphoinositide-3 Kinase Inhibitors
  • Cyclin-Dependent Kinase Inhibitor p27
  • 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
  • Estradiol
  • Proto-Oncogene Proteins c-akt