Abstract
The sequence of the herpes simplex virus type 2 (HSV-2) latency-associated transcript (LAT) region resembles that of HSV-1 only where the LATs overlap ICP0 and in the putative promoter region. Otherwise, the LAT 5' ends, kinetics of expression, and promoter elements are mostly conserved between HSV-1 and HSV-2. The remaining differences between the LATs could contribute to each virus's distinctive pattern of reactivation.
MeSH terms
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Amino Acid Sequence
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Base Sequence
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Chloramphenicol O-Acetyltransferase / genetics
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Chloramphenicol O-Acetyltransferase / metabolism
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Cloning, Molecular
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DNA, Viral / genetics
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Gene Expression
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Genes, Viral*
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Humans
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Kinetics
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Molecular Sequence Data
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Oligonucleotide Probes
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Open Reading Frames
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Promoter Regions, Genetic*
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Restriction Mapping
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Simplexvirus / genetics*
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TATA Box
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Transcription, Genetic*
Substances
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DNA, Viral
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Oligonucleotide Probes
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Chloramphenicol O-Acetyltransferase
Associated data
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GENBANK/M55615
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GENBANK/M64578
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GENBANK/M64579
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GENBANK/M64580
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GENBANK/M64581
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GENBANK/M64582
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GENBANK/M64583
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GENBANK/M69065
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GENBANK/M80192
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GENBANK/S57561