Induction of withdrawal-like symptoms in a small randomized, controlled trial of opioid blockade in frequent tanners

Mandeep Kaur; Anthony Liguori; Wei Lang; Stephen R Rapp; Alan B Fleischer Jr; Steven R Feldman

doi:10.1016/j.jaad.2005.11.1059

Induction of withdrawal-like symptoms in a small randomized, controlled trial of opioid blockade in frequent tanners

J Am Acad Dermatol. 2006 Apr;54(4):709-11. doi: 10.1016/j.jaad.2005.11.1059.

Authors

Mandeep Kaur¹, Anthony Liguori, Wei Lang, Stephen R Rapp, Alan B Fleischer Jr, Steven R Feldman

Affiliation

¹ Center for Dermatology Research, Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1071, USA.

PMID: 16546596
DOI: 10.1016/j.jaad.2005.11.1059

Abstract

Frequent tanning has reinforcing properties. We tested whether opioid antagonism blocks potential reinforcing effect of indoor tanning in 8 frequent tanners and 8 infrequent tanner control subjects. Opioid blockade reduced ultraviolet preference in frequent tanners. Four of 8 frequent tanners, but no infrequent tanners, exhibited withdrawal-like symptoms with naltrexone administration. A limitation of this study is its small size.

Publication types

Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Beauty Culture*
Behavior, Addictive / drug therapy*
Double-Blind Method
Humans
Naltrexone / adverse effects
Naltrexone / therapeutic use*
Narcotic Antagonists / adverse effects
Narcotic Antagonists / therapeutic use*
Skin / radiation effects*
Substance Withdrawal Syndrome / etiology
Ultraviolet Rays*

Substances

Narcotic Antagonists
Naltrexone

Grants and funding

DA14014-01/DA/NIDA NIH HHS/United States