Papillary carcinoma of the breast in a male patient with a treated prostatic carcinoma diagnosed by fine-needle aspiration biopsy: a case report and review of the literature

Diagn Cytopathol. 2006 Mar;34(3):214-7. doi: 10.1002/dc.20402.

Abstract

Papillary carcinoma of the male breast is very rare. In this case report, we describe the cytologic, histologic, immunohistochemical, and radiological findings of a papillary carcinoma of male breast. A 67-yr-old man, who had a previous history of prostatic adenocarcinoma, presented with a retroareolar painless mass. There was no known history of breast cancer in his family. A fine-needle aspiration biopsy (FNAB) was performed. Cytological examination revealed a cellular aspirate with three-dimensional papillary clusters. A diagnosis of papillary lesion favoring papillary carcinoma was rendered. Immunohistochemical staining of the cell-block of the FNAB revealed the presence of mammaglobin, and the absence of prostatic specific antigen. The patient underwent lumpectomy, which showed a moderately differentiated infiltrating papillary carcinoma with adjacent areas of ductal carcinoma in situ. FNAB is a useful technique in identifying male breast carcinoma. In conjunction with ancillary studies, this procedure can effectively differentiate between a primary versus metastatic lesion.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adenocarcinoma / pathology
  • Adenocarcinoma / therapy*
  • Aged
  • Biopsy, Fine-Needle
  • Breast Neoplasms, Male / chemistry
  • Breast Neoplasms, Male / diagnosis
  • Breast Neoplasms, Male / pathology*
  • Carcinoma, Papillary / chemistry
  • Carcinoma, Papillary / diagnosis
  • Carcinoma, Papillary / pathology*
  • Diagnosis, Differential
  • Humans
  • Immunohistochemistry
  • Male
  • Mammaglobin A
  • Neoplasm Metastasis
  • Neoplasm Proteins / analysis
  • Neoplasms, Second Primary / diagnosis
  • Neoplasms, Second Primary / pathology*
  • Prostate-Specific Antigen / analysis
  • Prostatic Neoplasms / pathology
  • Prostatic Neoplasms / therapy*
  • Uteroglobin / analysis

Substances

  • Mammaglobin A
  • Neoplasm Proteins
  • SCGB2A2 protein, human
  • Uteroglobin
  • Prostate-Specific Antigen