The Irukandji syndrome is a set of severe systemic symptoms observed after envenomation by some tropical jellyfish. The syndrome was first described in Northern Australia where Carukia barnesi was identified as the offending species. A recent report from Florida described three Irukandji-like syndromes in the Caribbean area. The purpose of this report is to describe a similar case involving a healthy young man who developed systemic symptoms after being stung by an unidentified jellyfish in Guadeloupe (French West Indies). These case reports suggest that jellyfish envenomation may not be unusual in the Caribbean.