Abstract
Oral immunization of healthy adults with 10(7) CFU BCG Moreau Rio de Janeiro was well tolerated and significantly boosted gamma interferon responses to purified protein derivative, Ag85, and MPB70 from previous childhood intradermal BCG immunization. Oral BCG offers the possibility of a needle-free tuberculosis vaccine and of boosting the protective immunity from intradermal tuberculosis vaccines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Oral
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Adult
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Cells, Cultured
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Cytokines / biosynthesis*
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Female
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Humans
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Immunity, Cellular
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Immunization, Secondary*
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Injections, Intradermal
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Male
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Mycobacterium bovis / immunology*
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Mycobacterium tuberculosis / immunology*
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Skin / immunology*
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Skin / metabolism
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Skin / microbiology
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Tuberculin / immunology
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Tuberculosis / immunology
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Tuberculosis / prevention & control
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Tuberculosis Vaccines / administration & dosage
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Tuberculosis Vaccines / immunology*
Substances
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Cytokines
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Tuberculin
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Tuberculosis Vaccines