Abstract
The effects of the main constituent ginsenoside Re in ginseng and its metabolite, ginsenoside Rh1, were investigated in 12-O-tetradecanoylphorbol 13-acetate (TPA)- and oxazolone-induced mouse ear dermatitis models. Ginsenoside Rh1 potently suppressed the TPA- and oxazolone-induced swellings as well as mRNA expression levels of cyclooxygenase-2, IL-1beta and TNF-alpha, although these were only weakly inhibited by ginsenoside Re.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Cutaneous
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Animals
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Dermatitis / drug therapy*
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Dermatitis / etiology
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Dermatitis / pathology
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Disease Models, Animal
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Dose-Response Relationship, Drug
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Ginsenosides / administration & dosage
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Ginsenosides / pharmacology*
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Ginsenosides / therapeutic use
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Keratolytic Agents / administration & dosage
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Keratolytic Agents / pharmacology*
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Keratolytic Agents / therapeutic use
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Mice
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Mice, Inbred ICR
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Oxazolone
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Panax* / metabolism
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Phytotherapy*
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Plant Roots
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Tetradecanoylphorbol Acetate
Substances
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Ginsenosides
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Keratolytic Agents
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Oxazolone
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ginsenoside Re
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ginsenoside Rh1
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Tetradecanoylphorbol Acetate