Abstract
A ciprofloxacin-resistant Escherichia coli isolate, isolate 1B, was obtained from a urinary specimen of a Canadian patient treated with norfloxacin for infection due to a ciprofloxacin-susceptible isolate, isolate 1A. Both isolates harbored a plasmid-encoded sul1-type integron with qnrA1 and blaVEB-1 genes. Isolate 1B had amino acid substitutions in gyrase and topoisomerase.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents / pharmacology*
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Base Sequence
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Ciprofloxacin / pharmacology
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Conjugation, Genetic
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Drug Resistance, Bacterial
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Escherichia coli / drug effects*
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Escherichia coli / enzymology
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Escherichia coli / genetics
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Fluoroquinolones / pharmacology*
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Molecular Sequence Data
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Plasmids*
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beta-Lactamases / genetics*
Substances
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Anti-Infective Agents
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Fluoroquinolones
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Ciprofloxacin
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beta-Lactamases