The benefit of pulsatile lavage on cement penetration in femoral cancellous bone is well known. The aim of this study was to determine the influence of different jet-lavage systems on cement penetration in a standardized cadaver study. Four different jet-lavage systems were compared (right vs left) in 30 paired human femora. After broaching, the femoral canal was lavaged with 1 l saline. The specimens were embedded in plastic pots, bone cement was applied in a retrograde manner and cement was pressurized using a standard pressure protocol with a constant force of 3,000 N. Horizontal sections were obtained at predefined levels using an automatic saw. Microradiographs were taken and analysed using image analysis to assess the extent of cement penetration. There were no significant differences in cement penetration into cancellous bone using the different jet-lavage systems. This technique is of great importance for obtaining a good interdigitation with cancellous bone. The different jet-lavage systems investigated in our study, however, seemed to be equally effective.