Magnetic nanoparticles applied in electrochemical detection of controllable DNA hybridization

Xiaoli Zhu; Kun Han; Genxi Li

doi:10.1021/ac051962x

Magnetic nanoparticles applied in electrochemical detection of controllable DNA hybridization

Anal Chem. 2006 Apr 1;78(7):2447-9. doi: 10.1021/ac051962x.

Authors

Xiaoli Zhu¹, Kun Han, Genxi Li

Affiliation

¹ Department of Biochemistry and National Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, 210093 Nanjing, P. R. China.

PMID: 16579633
DOI: 10.1021/ac051962x

Abstract

Electrochemical detection of hybridized DNA strands was achieved with a magnetic nanoparticle modified electrode and the commonly used electrochemical couple K3[Fe(CN)6]/K4[Fe(CN)6]. The detection proved to be fast and very simple. Furthermore, magnetic nanoparticles could be employed to control the DNA hybridization process. An inhibited or an enhanced degree of hybridizing could be produced.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Sequence
Biosensing Techniques / methods*
DNA / analysis*
DNA / chemistry
Electrochemistry
Ferrocyanides / chemistry
Ferrosoferric Oxide / chemistry
Magnetics*
Nanoparticles / chemistry*
Nucleic Acid Hybridization / methods*
Oxidation-Reduction
Silanes / chemistry

Substances

Ferrocyanides
Silanes
DNA
potassium ferrocyanide
Ferrosoferric Oxide