New chiral synthons for efficient introduction of bispropionates via stereospecific oxonia-cope rearrangements

J Am Chem Soc. 2006 Apr 12;128(14):4568-9. doi: 10.1021/ja061082f.

Abstract

Compounds 1 and 2 are novel synthons for bispropionate synthesis, undergoing stereospecific Lewis acid-catalyzed transfer of the bispropionate unit with a variety of aldehydes, including alpha-chiral aldehydes. Thus 1 leads to the E-alkene bispropionate 3 with anti-stereochemistry, whereas diastereomer 2 gives the Z-alkene product 4, under mild conditions and with complete stereospecificity. The efficacy of this methodology is demonstrated in a short synthesis of invictolide beginning with 2 and (R)-2-methylpentanal.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Acetates / chemistry*
  • Aldehydes / chemistry
  • Diphosphonates / chemistry*
  • Hydrogen Peroxide / chemistry*
  • Propionates / chemical synthesis
  • Propionates / chemistry*
  • Pyrones / chemical synthesis
  • Pyrones / chemistry*
  • Stereoisomerism

Substances

  • Acetates
  • Aldehydes
  • Diphosphonates
  • Oxonia Active
  • Propionates
  • Pyrones
  • invictolide
  • Hydrogen Peroxide