Abstract
Sinesterases that intervene in cAMP and oGMP equilibrium in the cytoplasm of mast cells are activated by the adrenergic system through beta-receptors. A study was made on 96 atopic patients with mono sensitization to Dermatophagoides pteronissinus, in 3 groups. Radioligands were used to quantitate the number of beta receptors. In the control group mean no/cell was 541, bronchial symptomatic patients had 327 and nasal symptomatics 348. Asymptomatic patients were similar to controls. The results were similar with pollen-sensitive patients. Beta receptor decrease is a consequence of clinical allergy in atopic patients and is secondary to the immunological events that follow antigen-antibody reactions and cell membrane changes.
MeSH terms
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Adenylyl Cyclases / metabolism
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Allergens / immunology
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Animals
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Asthma / etiology
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Asthma / immunology
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Asthma / metabolism*
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Bronchial Provocation Tests
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Bronchial Spasm / physiopathology
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Cyclic AMP / metabolism
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Cyclic GMP / metabolism
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Enzyme Activation
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Humans
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Hypersensitivity, Immediate / complications
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Hypersensitivity, Immediate / immunology
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Hypersensitivity, Immediate / metabolism*
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Mast Cells / chemistry*
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Mites / immunology
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Phosphoric Diester Hydrolases / metabolism
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Receptors, Adrenergic, beta / analysis*
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Receptors, Adrenergic, beta / physiology
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Rhinitis, Allergic, Seasonal / immunology
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Rhinitis, Allergic, Seasonal / metabolism
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Signal Transduction
Substances
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Allergens
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Receptors, Adrenergic, beta
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Cyclic AMP
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Phosphoric Diester Hydrolases
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Adenylyl Cyclases
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Cyclic GMP