Abstract
We describe four patients with relapsing remitting multiple sclerosis (RRMS) who experienced a relapse with acute onset of painful sensations. Pain sensations disappeared in two of them and markedly reduced in the other ones after repeat application of intrathecal triamcinolone acetonide (TCA) following a prior unsuccessful treatment with intravenous steroids. TCA administration was well tolerated and no serious side effects occurred. Repeated intrathecal TCA injection may provide a substantial benefit in RRMS patients with acute onset of pain due to an inflammatory lesion within the spinal cord.
MeSH terms
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Adult
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Anti-Inflammatory Agents / administration & dosage
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Anti-Inflammatory Agents / therapeutic use
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Female
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Humans
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Immunosuppressive Agents / administration & dosage
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Immunosuppressive Agents / therapeutic use
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Injections, Spinal
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Magnetic Resonance Imaging
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Multiple Sclerosis, Relapsing-Remitting / drug therapy*
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Multiple Sclerosis, Relapsing-Remitting / physiopathology
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Pain / prevention & control*
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Spinal Cord / pathology
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Triamcinolone Acetonide / administration & dosage
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Triamcinolone Acetonide / therapeutic use*
Substances
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Anti-Inflammatory Agents
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Immunosuppressive Agents
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Triamcinolone Acetonide