[Cases of advanced cholangiocarcinoma showing partial response by the combination chemotherapy including protracted continuous infusion of 5-FU combined with intravenous administration of low-dose leucovorin and intra-arterial administration of MMC and CQ]

K Tsushima; Y Sakata; Y Shiratori; J Sakamoto; J Koeda; Y Yamada; N Soma; K Tamura; A Yoshiwara; Y Soma

[Cases of advanced cholangiocarcinoma showing partial response by the combination chemotherapy including protracted continuous infusion of 5-FU combined with intravenous administration of low-dose leucovorin and intra-arterial administration of MMC and CQ]

Gan To Kagaku Ryoho. 1991 Dec;18(15):2603-5.

[Article in Japanese]

Authors

K Tsushima¹, Y Sakata, Y Shiratori, J Sakamoto, J Koeda, Y Yamada, N Soma, K Tamura, A Yoshiwara, Y Soma, et al.

Affiliation

¹ First Dept. of Internal Medicine, Hirosaki University School of Medicine, Japan.

PMID: 1660702

Abstract

We treated a patient with advanced cholangiocarcinoma with a new combination chemotherapy (modified MQF). The regimen consisted of intra-arterial administration of MMC (20 mg/body) and CQ (4 mg/body), protracted continuous infusion of 5-FU (500 mg/body) and intravenous administration of low-dose leucovorin (30 mg/body). More than 50% reduction in the liver tumor for over 4 weeks was obtained by the therapy. As for toxicity, diarrhea and stomatitis were observed.

Publication types

Case Reports
English Abstract

MeSH terms

Adenoma, Bile Duct / drug therapy*
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Bile Duct Neoplasms / drug therapy*
Carbazilquinone / administration & dosage
Drug Administration Schedule
Fluorouracil / administration & dosage
Hepatic Artery
Humans
Infusions, Intra-Arterial
Infusions, Intravenous
Leucovorin / administration & dosage
Male
Middle Aged
Mitomycin / administration & dosage

Substances

Carbazilquinone
Mitomycin
Leucovorin
Fluorouracil