Abstract
A structurally characterized mixed-valent tetranuclear ruthenium-oxo oxalato cluster exhibits anti-viral activities toward R5- and X4-tropic HIV-1, and possesses cytoprotective activity toward HIV-1 infected cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / chemistry*
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Anti-HIV Agents / pharmacology
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Crystallography, X-Ray
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Enzyme-Linked Immunosorbent Assay
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Flow Cytometry
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HIV Reverse Transcriptase / antagonists & inhibitors
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HIV-1 / physiology
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Humans
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In Situ Nick-End Labeling
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Organometallic Compounds / chemistry
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Organometallic Compounds / pharmacology
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Oxalates / chemistry*
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Oxalates / pharmacology
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Ruthenium / chemistry*
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Ruthenium / pharmacology
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T-Lymphocytes / virology
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Virus Replication / drug effects
Substances
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Anti-HIV Agents
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Organometallic Compounds
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Oxalates
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Ruthenium
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HIV Reverse Transcriptase