Abstract
We tested the effects of various doses of the triazolobenzodiazepine alprazolam on behavioral, hormonal, and neurochemical responses of infant rhesus monkeys under three conditions of separation from their mothers: alone, in the presence of a human who stared at them, and in the presence of a human who avoided eye contact. Alprazolam affected stress-induced responses in all three of these classes. Unrelated to its effects on the stress response, alprazolam appears to reduce the function of brain dopamine systems.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adrenocorticotropic Hormone / blood
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Alprazolam / blood
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Alprazolam / pharmacology*
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Animals
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Behavior, Animal / drug effects*
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Catecholamines / cerebrospinal fluid
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Corticotropin-Releasing Hormone / cerebrospinal fluid
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Fear / drug effects*
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Female
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Growth Hormone / blood
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Hydrocortisone / blood
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Macaca mulatta
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Male
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Neurosecretory Systems / drug effects*
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Radioimmunoassay
Substances
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Catecholamines
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Adrenocorticotropic Hormone
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Growth Hormone
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Corticotropin-Releasing Hormone
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Hydrocortisone
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Alprazolam