ACE inhibition and glomerular repair: restructuring or regeneration?

J A Joles; B Braam; M C Verhaar

doi:10.1038/sj.ki.5000237

ACE inhibition and glomerular repair: restructuring or regeneration?

Kidney Int. 2006 Apr;69(7):1105-7. doi: 10.1038/sj.ki.5000237.

Authors

J A Joles¹, B Braam, M C Verhaar

Affiliation

¹ Department of Nephrology, University Medical Center Utrecht, Utrecht, The Netherlands. [email protected]

PMID: 16609678
DOI: 10.1038/sj.ki.5000237

Abstract

In this issue of Kidney International, Andrea Remuzzi et al. convincingly demonstrate glomerular repair in spontaneous renal disease by ACE inhibition. These findings provoke questions about how ACE inhibition (or AT1R blockade) can on the one hand actually repair some diseased kidneys while on the other interfering with normal renal development or the recovery of other diseased kidneys.

Publication types

Comment

MeSH terms

Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
Animals
Capillaries / drug effects
Capillaries / physiopathology
Disease Models, Animal
Disease Progression
Glomerulosclerosis, Focal Segmental / drug therapy*
Kidney Glomerulus / blood supply
Kidney Glomerulus / drug effects
Kidney Glomerulus / physiopathology*
Male
Rats
Rats, Inbred Strains
Regeneration / drug effects

Substances

Angiotensin-Converting Enzyme Inhibitors