[Regional activity of enkephalin- and angiotensin II-forming peptidases in the rat brain and other peripheral tissues with different craving for ethanol]

O A Gomazkov; A D Panfilov; A P Rostovtsev; N V Komissarova; V V Fomin; O O Grigor'iants

[Regional activity of enkephalin- and angiotensin II-forming peptidases in the rat brain and other peripheral tissues with different craving for ethanol]

Vopr Med Khim. 1991 Jul-Aug;37(4):33-7.

[Article in Russian]

Authors

O A Gomazkov, A D Panfilov, A P Rostovtsev, N V Komissarova, V V Fomin, O O Grigor'iants

PMID: 1661050

Abstract

Activities of enkephalin- and angiotensin II-forming enzymes (carboxypeptidase H and angiotensin-converting enzyme, ACE) were changed in different brain regions and peripheral tissues of rats with various alcohol motivation. The carboxypeptidase H activity was elevated in midbrain, striatum, hypophysis and adrenal glands, while the ACE activity was increased in hypophysis and striatum. The ACE activity was decreased two-fold in thalamo-hypothalamic region of ethanol-preferring rats.

Publication types

English Abstract

MeSH terms

Adrenal Glands / enzymology
Alcohol Drinking / metabolism*
Animals
Body Weight / drug effects
Brain / enzymology*
Carboxypeptidase H
Carboxypeptidases / metabolism*
Endopeptidases / metabolism*
Ethanol / administration & dosage
Ethanol / pharmacology*
Male
Pain / physiopathology
Peptidyl-Dipeptidase A / metabolism*
Rats
Rats, Inbred Strains
Sensory Thresholds / drug effects

Substances

Ethanol
Carboxypeptidases
Endopeptidases
Peptidyl-Dipeptidase A
Carboxypeptidase H