Cutaneous leukocytoclastic vasculitis in a child with interleukin-12 receptor beta-1 deficiency

J Pediatr. 2006 Mar;148(3):407-9. doi: 10.1016/j.jpeds.2005.10.003.

Abstract

We report a patient with complete interleukin-12 receptor beta-1 deficiency associated with cutaneous leukocytoclastic vasculitis. The patient experienced Bacille Calmette Guérin, Mycobacterium chelonae, and Salmonella enteritidis infection. Vasculitis affecting both small arteries and postcapillary venules due to deposition of immune complexes was probably caused by S. enteritidis and/or M. chelonae infection.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Cattle
  • Child
  • Consanguinity
  • Female
  • Humans
  • Mycobacterium Infections, Nontuberculous / diagnosis
  • Mycobacterium Infections, Nontuberculous / drug therapy
  • Mycobacterium bovis / isolation & purification
  • Mycobacterium chelonae / isolation & purification
  • Psoas Abscess / microbiology
  • Receptors, Interleukin / deficiency*
  • Receptors, Interleukin-12
  • Salmonella Infections / diagnosis
  • Salmonella Infections / drug therapy
  • Salmonella enteritidis / isolation & purification
  • Splenomegaly / surgery
  • Tuberculosis, Bovine / diagnosis
  • Tuberculosis, Bovine / drug therapy
  • Vasculitis, Leukocytoclastic, Cutaneous / drug therapy
  • Vasculitis, Leukocytoclastic, Cutaneous / microbiology*

Substances

  • Receptors, Interleukin
  • Receptors, Interleukin-12