Abstract
Hepatitis caused by mouse hepatitis virus (MHV-A59), a murine coronavirus, is accompanied by direct infection and replication of virus within the liver. We demonstrate here that the aminoglycoside hygromycin B is able to eliminate MHV-A59 infection from mouse peritoneal macrophages and cultured liver cells in vitro and is also able to reduce levels of virus replication and necrotic liver foci in vivo.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Survival / drug effects
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Cells, Cultured
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Fluorescent Antibody Technique
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Hepatitis, Viral, Animal / drug therapy*
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Hepatitis, Viral, Animal / microbiology
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Hygromycin B / therapeutic use*
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Hygromycin B / toxicity
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Liver / microbiology
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Macrophages / drug effects
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Macrophages / microbiology
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Mice
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Mice, Inbred A
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Mice, Inbred BALB C
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Murine hepatitis virus*
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Virus Replication / drug effects