Hygromycin B therapy of a murine coronaviral hepatitis

Antimicrob Agents Chemother. 1991 Oct;35(10):2125-7. doi: 10.1128/AAC.35.10.2125.

Abstract

Hepatitis caused by mouse hepatitis virus (MHV-A59), a murine coronavirus, is accompanied by direct infection and replication of virus within the liver. We demonstrate here that the aminoglycoside hygromycin B is able to eliminate MHV-A59 infection from mouse peritoneal macrophages and cultured liver cells in vitro and is also able to reduce levels of virus replication and necrotic liver foci in vivo.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Survival / drug effects
  • Cells, Cultured
  • Fluorescent Antibody Technique
  • Hepatitis, Viral, Animal / drug therapy*
  • Hepatitis, Viral, Animal / microbiology
  • Hygromycin B / therapeutic use*
  • Hygromycin B / toxicity
  • Liver / microbiology
  • Macrophages / drug effects
  • Macrophages / microbiology
  • Mice
  • Mice, Inbred A
  • Mice, Inbred BALB C
  • Murine hepatitis virus*
  • Virus Replication / drug effects

Substances

  • Hygromycin B