New potential inhibitors of cyclin-dependent kinase 4: design and synthesis of pyrido[2,3-d]pyrimidine derivatives under microwave irradiation

Shujiang Tu; Jinpeng Zhang; Xiaotong Zhu; Jianing Xu; Yan Zhang; Qian Wang; Runhong Jia; Bo Jiang; Junyong Zhang

doi:10.1016/j.bmcl.2006.03.084

New potential inhibitors of cyclin-dependent kinase 4: design and synthesis of pyrido[2,3-d]pyrimidine derivatives under microwave irradiation

Bioorg Med Chem Lett. 2006 Jul 1;16(13):3578-81. doi: 10.1016/j.bmcl.2006.03.084. Epub 2006 Apr 18.

Authors

Shujiang Tu¹, Jinpeng Zhang, Xiaotong Zhu, Jianing Xu, Yan Zhang, Qian Wang, Runhong Jia, Bo Jiang, Junyong Zhang

Affiliation

¹ Department of Chemistry, Xuzhou Normal University, Key Laboratory of Biotechnology on Medical Plant, Xuzhou, Jiangsu 221009, PR China. [email protected]

PMID: 16621547
DOI: 10.1016/j.bmcl.2006.03.084

Abstract

A simple and efficient synthesis of 2-amino pyrido[2,3-d]pyrimidine derivatives was accomplished via a three-component reaction under microwave irradiation without catalyst. This method had many dramatic advantages such as the short reaction time, high yield, and broad substrate scope, as well as convenient operation. We provide new series of potential biologically active compounds as inhibitors of Cdk4.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cyclin-Dependent Kinase 4 / antagonists & inhibitors*
Drug Design
Enzyme Inhibitors / chemical synthesis*
Enzyme Inhibitors / pharmacology*
Enzyme Inhibitors / radiation effects
Microwaves
Molecular Structure
Pyridines / chemical synthesis*
Pyridines / pharmacology*
Pyridines / radiation effects
Pyrimidines / chemical synthesis*
Pyrimidines / pharmacology*
Pyrimidines / radiation effects
Stereoisomerism
Structure-Activity Relationship

Substances

Enzyme Inhibitors
Pyridines
Pyrimidines
Cyclin-Dependent Kinase 4