Abstract
This paper reports the synthesis of new chlorin-polyamine conjugates designed to improve the targeting of cancer cells. Photocytotoxic activity of these photosensitizers was tested against human chronic myelogenous leukemia cells (K562) and compared to the effects of Photofrin II and chlorin e6.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cell Proliferation / radiation effects
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Humans
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Molecular Structure
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Photosensitizing Agents / chemical synthesis*
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Photosensitizing Agents / chemistry
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Photosensitizing Agents / toxicity*
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Polyamines / chemical synthesis
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Polyamines / chemistry*
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Polyamines / toxicity*
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Porphyrins / chemistry*
Substances
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Photosensitizing Agents
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Polyamines
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Porphyrins
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chlorin