Abstract
We report that hbhA is differentially regulated during Mycobacterium tuberculosis infection. Upregulation was observed in epithelial cell infection but not in macrophage infection and in the lungs but not in the spleens of infected mice, and it was greater during the early steps of infection, when bacilli disseminate from the site of primary infection.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bacterial Proteins / genetics*
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Cytoskeletal Proteins / genetics
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Female
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Gene Expression Regulation, Bacterial*
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Lung / metabolism*
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Lung / microbiology
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Lung / pathology
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Membrane Proteins / genetics*
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Mice
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Mice, Inbred C57BL
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Organ Specificity
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Recombinant Proteins / biosynthesis
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Spleen / metabolism*
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Spleen / microbiology
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Up-Regulation
Substances
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Bacterial Proteins
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Cytoskeletal Proteins
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FtsZ protein, Bacteria
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HbhA protein, Mycobacterium tuberculosis
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Membrane Proteins
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Recombinant Proteins