Abstract
Previous studies determined that the Chlamydia glycan contains a high-mannose oligosaccharide, which is involved in attachment and infectivity of the organism, and that removal of the glycan decreases infectivity in vitro. The present study demonstrates that treatment of the organism with N-glycanase decreases or ablates infectivity in vivo.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Chlamydia Infections / drug therapy
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Chlamydia Infections / etiology
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Chlamydia Infections / prevention & control*
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Lung Diseases / prevention & control*
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Mice
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Oligosaccharides / metabolism*
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Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase / pharmacology
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Polysaccharides / physiology*
Substances
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Oligosaccharides
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Polysaccharides
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Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase