Abstract
Intratracheal delivery of aerosolized monoclonal antibodies with specificity for Yersinia pestis LcrV and F1 antigens protected mice in a model of pneumonic plague. These data support the utility of inhaled antibodies as a fast-acting postexposure treatment for plague.
MeSH terms
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Aerosols
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Animals
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Antibodies, Bacterial / administration & dosage*
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Antibodies, Monoclonal / administration & dosage*
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Antigens, Bacterial / immunology*
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Bacterial Proteins / immunology*
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Female
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Mice
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Mice, Inbred BALB C
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Plague / prevention & control*
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Pore Forming Cytotoxic Proteins
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Yersinia pestis / immunology*
Substances
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Aerosols
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Antibodies, Bacterial
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Antibodies, Monoclonal
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Antigens, Bacterial
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Bacterial Proteins
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LcrV protein, Yersinia
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Pore Forming Cytotoxic Proteins
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caf1 protein, Yersinia pestis