Gut hormones ghrelin, PYY, and GLP-1 in the regulation of energy balance [corrected] and metabolism

Endocrine. 2006 Feb;29(1):61-71. doi: 10.1385/endo:29:1:61.

Abstract

The first hormone discovered in the gastrointestinal tract was secretin, isolated from duodenal mucosa. Some years later, two additional gastrointestinal hormones, gastrin and cholecystokinin (CCK), were discovered, but it was not until the 1970s that gastrointestinal endocrinology studies became more prevalent, resulting in the discovery of many more hormones. Here, we examine the role of gut hormones in energy balance regulation and their possible use as pharmaceutical targets for obesity.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Obesity Agents / pharmacology
  • Anti-Obesity Agents / therapeutic use
  • Appetite Regulation / drug effects
  • Appetite Regulation / physiology
  • Body Weight / drug effects
  • Body Weight / physiology
  • Energy Metabolism / drug effects
  • Energy Metabolism / physiology*
  • Ghrelin
  • Glucagon-Like Peptide 1 / analysis
  • Glucagon-Like Peptide 1 / physiology*
  • Glucagon-Like Peptides / physiology
  • Homeostasis / drug effects
  • Homeostasis / physiology
  • Humans
  • Obesity / drug therapy
  • Obesity / physiopathology
  • Oxyntomodulin
  • Peptide Hormones / analysis
  • Peptide Hormones / physiology*
  • Peptide YY / analysis
  • Peptide YY / physiology*

Substances

  • Anti-Obesity Agents
  • Ghrelin
  • Oxyntomodulin
  • Peptide Hormones
  • Peptide YY
  • Glucagon-Like Peptides
  • Glucagon-Like Peptide 1