First AID (activation-induced cytidine deaminase) is needed to produce high affinity isotype-switched antibodies

J Biol Chem. 2006 Jun 23;281(25):16833-16836. doi: 10.1074/jbc.R600006200. Epub 2006 Apr 19.

Authors

Ronda Bransteitter¹, Jessica L Sneeden¹, Sariah Allen¹, Phuong Pham¹, Myron F Goodman²

Affiliations

¹ Department of Biological Sciences, Molecular and Computational Biology Section, University of Southern California, Los Angeles, California 90089-2910.
² Department of Biological Sciences, Molecular and Computational Biology Section, University of Southern California, Los Angeles, California 90089-2910. Electronic address: [email protected].

PMID: 16624806
DOI: 10.1074/jbc.R600006200

No abstract available

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

AICDA (Activation-Induced Cytidine Deaminase)
Animals
Antibodies / chemistry*
Cytidine Deaminase / metabolism
Cytidine Deaminase / physiology*
Cytosine Deaminase / metabolism
Cytosine Deaminase / physiology*
Gene Expression Regulation
Humans
Immune System
Immunoglobulin Class Switching
Immunoglobulin Isotypes / chemistry
Immunoglobulins / chemistry
Models, Genetic

Substances

Antibodies
Immunoglobulin Isotypes
Immunoglobulins
AICDA (Activation-Induced Cytidine Deaminase)
Cytosine Deaminase
Cytidine Deaminase

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