DNA breakage caused by hydrogen peroxide produced during the metabolism of 2-methyl-1,4-naphthoquinone (menadione) does not contribute to the cytotoxic action of the quinone

Biochem Pharmacol. 1991 Dec 11:42 Suppl:S220-2. doi: 10.1016/0006-2952(91)90415-2.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Division / drug effects
  • Cell Line / drug effects
  • Cell Survival / drug effects
  • Cricetinae
  • Cricetulus
  • DNA Damage*
  • DNA, Single-Stranded / drug effects
  • Hydrogen Peroxide / metabolism*
  • Phenanthrolines / pharmacology
  • Superoxides / metabolism
  • Thymidine / metabolism
  • Vitamin K / toxicity*

Substances

  • DNA, Single-Stranded
  • Phenanthrolines
  • Superoxides
  • Vitamin K
  • Hydrogen Peroxide
  • Thymidine