Abstract
Intravenous infection of C57BL/6 and C57BL/10 mice with low doses of a highly virulent strain of Mycobacterium avium (ATCC 25291) led to the development of granulomas that underwent necrosis. In contrast, neither BALB/c nor DBA/1 mice developed granuloma necrosis after such infection despite a similar course of mycobacterial proliferation. Studies with C57BL/10 mice congenic for the Hc locus revealed that an intact complement C5 gene is required for granuloma necrosis. On the other hand, genetic disruption of the interleukin-10 gene in BALB/c mice made this strain susceptible to granuloma necrosis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cells, Cultured
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Female
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Granuloma / genetics*
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Granuloma / immunology
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Granuloma / pathology
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Interleukin-10 / biosynthesis
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Interleukin-10 / genetics
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Liver / microbiology
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Lung / microbiology
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Macrophages / immunology
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Mice
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Mice, Inbred BALB C
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Mice, Inbred C57BL
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Mice, Inbred DBA
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Mycobacterium avium* / growth & development
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Mycobacterium avium* / isolation & purification
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Mycobacterium avium* / pathogenicity
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Necrosis
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Polymerase Chain Reaction / methods
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Species Specificity
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Spleen / immunology
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Spleen / microbiology
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Tuberculosis / genetics*
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Tuberculosis / immunology
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Tuberculosis / pathology