Recent advances in neuroimaging have revolutionized the evaluation of the clinical syndrome of transient ischemic attack (TIA). Diffusion-weighted imaging demonstrates microinfarctions (< 1 cm(3)) in approximately 50% of patients with TIA, establishing that not all clinically transient spells are transient at the tissue level. The clinical syndrome of TIA that is associated with ischemic brain injury is called "transient symptoms with infarction" (TSI). TSI appears to be a different subset because it harbors higher risk of imminent stroke than "TIA with no infarction." Armed with the evidence of ischemia as the cause of transient spell, clinicians can pursue the most appropriate therapy for stroke prevention by targeting the underlying etiology of brain ischemia.