Abstract
MEDTA (minocycline-edetate calcium disodium), taurolidine (2%)-polyvinylpyrolidine (5%) (T/PVP), and ethanol as potential catheter lock solutions have a unique mechanism of action, broad-spectrum activity, and anticoagulant properties. Traditional lock solutions minocycline (M), rifampin (R), ciprofloxacin (C), and vancomycin, except pharmacologic concentrations of C and R and of M and R, were less effective than MEDTA and T/PVP.
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Anti-Infective Agents / pharmacology*
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Anticoagulants / pharmacology*
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Candida albicans / drug effects
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Candida albicans / growth & development
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Catheterization / adverse effects
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Catheters, Indwelling / adverse effects*
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Ciprofloxacin / pharmacology
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Colony Count, Microbial
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Dose-Response Relationship, Drug
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Drug Synergism
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Drug Therapy, Combination
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Edetic Acid / pharmacology
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Ethanol / pharmacology
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Humans
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In Vitro Techniques
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Microbial Sensitivity Tests
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Minocycline / pharmacology
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Pharmaceutical Preparations
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Pseudomonas aeruginosa / drug effects
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Pseudomonas aeruginosa / growth & development
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Rifampin / pharmacology
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Solutions
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Staphylococcus aureus / drug effects
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Staphylococcus aureus / growth & development
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Staphylococcus epidermidis / drug effects
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Staphylococcus epidermidis / growth & development
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Taurine / analogs & derivatives
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Taurine / pharmacology
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Thiadiazines / pharmacology
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Time Factors
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Vancomycin / pharmacology
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents
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Anticoagulants
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Pharmaceutical Preparations
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Solutions
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Thiadiazines
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Taurine
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Ethanol
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Ciprofloxacin
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Vancomycin
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taurolidine
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Edetic Acid
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Minocycline
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Rifampin