Abstract
An influenza B virus from an infant with no history of treatment or contact with neuraminidase inhibitors demonstrated a significant reduction in sensitivity to these drugs. Here, we describe the analysis of a mixed viral population that contained a novel D197E amino acid substitution that was responsible for this reduction.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetamides / pharmacology
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Acids, Carbocyclic
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Amino Acid Substitution
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Antiviral Agents / pharmacology
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Baculoviridae / genetics
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Base Sequence
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Cyclopentanes / pharmacology
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Drug Resistance, Viral / genetics*
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Enzyme Inhibitors / pharmacology*
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Enzyme Inhibitors / therapeutic use
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Female
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Guanidines / pharmacology
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Humans
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Infant
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Influenza B virus / drug effects*
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Influenza B virus / isolation & purification
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Influenza, Human / drug therapy*
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Influenza, Human / virology
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Inhibitory Concentration 50
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Neuraminidase / antagonists & inhibitors*
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Neuraminidase / genetics
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Oseltamivir
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Pyrans / pharmacology
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Recombinant Proteins / antagonists & inhibitors
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Sialic Acids / pharmacology
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Zanamivir
Substances
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Acetamides
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Acids, Carbocyclic
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Antiviral Agents
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Cyclopentanes
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Enzyme Inhibitors
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Guanidines
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Pyrans
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Recombinant Proteins
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Sialic Acids
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Oseltamivir
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Neuraminidase
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Zanamivir
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peramivir
Associated data
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GENBANK/DQ174087
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GENBANK/DQ174088