Abstract
Five new triterpenoid saponins, polygalasaponins E (1), F (2), G (3), H (4), and J (5), along with eight known ones (6-13), were isolated from the aerial parts of Polygala japonica. Their structures were established by chemical and spectroscopic means. Forced swimming tests on mice showed that saponins 1 and 4 significantly reduce the immobility status by 58.1% and 51.3% at a dosage of 100 mg/kg administrated orally once daily for 5 days, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Depressive Disorder
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Disease Models, Animal
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Drugs, Chinese Herbal* / administration & dosage
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Drugs, Chinese Herbal* / chemistry
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Drugs, Chinese Herbal* / isolation & purification
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Drugs, Chinese Herbal* / pharmacology
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Male
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Medicine, Chinese Traditional
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Mice
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Mice, Inbred ICR
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Molecular Structure
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Motor Activity / drug effects
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Motor Activity / physiology*
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Plants, Medicinal / chemistry*
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Polygala / chemistry*
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Saponins* / administration & dosage
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Saponins* / chemistry
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Saponins* / isolation & purification
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Saponins* / pharmacology
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Swimming
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Triterpenes* / administration & dosage
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Triterpenes* / chemistry
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Triterpenes* / isolation & purification
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Triterpenes* / pharmacology
Substances
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Drugs, Chinese Herbal
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Saponins
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Triterpenes