Abstract
Chromatographic investigation of an acetone extract of the octocoral Xenia florida afforded three new xenicane diterpenes, namely, florxenilide A (1), florxenilide B (2), and florxenilide C (3), in addition to seven known xenicane diterpenes and two known cadinene sesquiterpenes. Structures were elucidated through spectroscopic analysis, especially 2D NMR, and chemical derivatization. The absolute configuration of 1 was determined by NOESY, CD, and Mosher's methods. Florxenilides A (1) and B (2) exhibited cytotoxicity against human colon cancer (WiDr) cells at 4.5 and 3.7 muM, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anthozoa / chemistry*
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Antineoplastic Agents* / chemistry
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Antineoplastic Agents* / classification
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Antineoplastic Agents* / isolation & purification
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Antineoplastic Agents* / pharmacology
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Diterpenes* / chemistry
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Diterpenes* / classification
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Diterpenes* / isolation & purification
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Diterpenes* / pharmacology
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Drug Screening Assays, Antitumor
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Humans
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Molecular Structure
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Sesquiterpenes / chemistry
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Sesquiterpenes / classification
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology
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Taiwan
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Diterpenes
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Sesquiterpenes
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florxenilide A
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florxenilide B
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florxenilide C