Bisabolane sesquiterpenes from the roots of Ligularia cymbulifera

J Nat Prod. 2006 Apr;69(4):695-9. doi: 10.1021/np0505061.

Abstract

Eight new highly oxygenated bisabolane sesquiterpenes (1-8), of which one contains a chlorine atom, were obtained in a phytochemical investigation of the roots of Ligularia cymbulifera, and their structures were elucidated by interpretation of spectroscopic data. Their relative configurations were clarified by a detailed analysis of (1)H NMR coupling constants and by NOE experiments. Compounds 1-8 were evaluated for antimicrobial activity against three bacterial cultures and a yeast culture.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Infective Agents* / chemistry
  • Anti-Infective Agents* / isolation & purification
  • Anti-Infective Agents* / pharmacology
  • Asteraceae / chemistry*
  • Candida albicans / drug effects
  • Escherichia coli / drug effects
  • Methicillin Resistance
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Plant Roots / chemistry
  • Plants, Medicinal / chemistry*
  • Sesquiterpenes* / chemistry
  • Sesquiterpenes* / isolation & purification
  • Sesquiterpenes* / pharmacology
  • Staphylococcus aureus / drug effects

Substances

  • Anti-Infective Agents
  • Sesquiterpenes