Abstract
Eight new highly oxygenated bisabolane sesquiterpenes (1-8), of which one contains a chlorine atom, were obtained in a phytochemical investigation of the roots of Ligularia cymbulifera, and their structures were elucidated by interpretation of spectroscopic data. Their relative configurations were clarified by a detailed analysis of (1)H NMR coupling constants and by NOE experiments. Compounds 1-8 were evaluated for antimicrobial activity against three bacterial cultures and a yeast culture.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents* / chemistry
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Anti-Infective Agents* / isolation & purification
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Anti-Infective Agents* / pharmacology
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Asteraceae / chemistry*
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Candida albicans / drug effects
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Escherichia coli / drug effects
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Methicillin Resistance
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Microbial Sensitivity Tests
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Molecular Structure
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Plant Roots / chemistry
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Plants, Medicinal / chemistry*
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Sesquiterpenes* / chemistry
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Sesquiterpenes* / isolation & purification
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Sesquiterpenes* / pharmacology
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Staphylococcus aureus / drug effects
Substances
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Anti-Infective Agents
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Sesquiterpenes