Abstract
It was found, that injection of delta-receptors agonist dalargin before the occlusion of left anterior coronary artery in rats prevented the decrease of ventricular fibrillation threshold (VFT). An injection of naloxone in dose 0.5 mg/kg (for the blockade of mu-receptors only) had no influence on the VFT. Naloxone in dose 1 mg/kg (for the blockade peripheric mu- and delta-receptors) decreased VFT. An intraventricular infusion of dalargin (10 mkg) induced bradycardia and an increase of VFT. It was assumed that anti-arrhythmic effects of enkephalins in acute myocardial ischemia could be realized by an activation of peripheric delta-receptors and central mu-receptors.
MeSH terms
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Animals
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Anti-Arrhythmia Agents / pharmacology*
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Arrhythmias, Cardiac / drug therapy
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Arrhythmias, Cardiac / physiopathology*
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Enkephalin, Leucine-2-Alanine / analogs & derivatives
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Enkephalin, Leucine-2-Alanine / pharmacology
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Enkephalins / pharmacology*
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Enkephalins / therapeutic use
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Male
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Myocardial Infarction / physiopathology
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Naloxone / pharmacology
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Rats
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Receptors, Opioid / drug effects*
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Receptors, Opioid / physiology
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Receptors, Opioid, delta
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Receptors, Opioid, mu
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Ventricular Fibrillation / drug therapy
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Ventricular Fibrillation / physiopathology
Substances
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Anti-Arrhythmia Agents
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Enkephalins
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Receptors, Opioid
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Receptors, Opioid, delta
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Receptors, Opioid, mu
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Naloxone
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Enkephalin, Leucine-2-Alanine
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enkephalin-Leu, Ala(2)-Arg(6)-