Abstract
Renal cell carcinoma is an uncommon tumor in adults. Metastasis in the nasal fossa is rare, and can become apparent as a result of repeated epistaxis. We report a patient with renal cell carcinoma presenting with epistaxis secondary to a metastasis in the right nasal fossa. The primary tumor was treated with nephrectomy and the nasal fossa metastasis was treated successfully with embolization, chemoimmunotherapy, surgery, and radiotherapy. The presence of repeated epistaxis may very occasionally be the first symptom of renal cell carcinoma, and systemic treatment combined with local treatment may enable adequate control of the disease.
MeSH terms
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Adenocarcinoma, Clear Cell / pathology
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Adenocarcinoma, Clear Cell / secondary*
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Adenocarcinoma, Clear Cell / therapy
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Antimetabolites, Antineoplastic / therapeutic use
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Antineoplastic Agents, Phytogenic / therapeutic use
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Carcinoma, Renal Cell / pathology
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Carcinoma, Renal Cell / secondary*
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Carcinoma, Renal Cell / therapy
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Combined Modality Therapy
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Embolization, Therapeutic
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Epistaxis / etiology
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Fatal Outcome
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Fluorouracil / therapeutic use
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Humans
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Immunologic Factors / therapeutic use
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Interferon alpha-2
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Interferon-alpha / therapeutic use
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Interleukin-2 / therapeutic use
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Kidney Neoplasms / diagnosis*
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Kidney Neoplasms / pathology
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Kidney Neoplasms / therapy
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Lung Neoplasms / secondary
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Lung Neoplasms / surgery
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Lymph Node Excision
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Male
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Middle Aged
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Nasal Cavity*
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Nephrectomy
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Nose Neoplasms / diagnosis
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Nose Neoplasms / secondary*
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Nose Neoplasms / therapy
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Orchiectomy
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Pneumonectomy / methods
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Radiotherapy, Adjuvant
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Recombinant Proteins
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Testicular Neoplasms / secondary
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Testicular Neoplasms / surgery
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Tomography, X-Ray Computed
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Vinblastine / therapeutic use
Substances
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Antimetabolites, Antineoplastic
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Antineoplastic Agents, Phytogenic
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Immunologic Factors
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Interferon alpha-2
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Interferon-alpha
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Interleukin-2
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Recombinant Proteins
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Vinblastine
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Fluorouracil