Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-alkyl-4-hydroxyquinolon-3-yl-benzothiadiazine sulfamides

A Chris Krueger; Darold L Madigan; Wen W Jiang; Warren M Kati; Dachun Liu; Yaya Liu; Clarence J Maring; Sherie Masse; Keith F McDaniel; Tim Middleton; Hongmei Mo; Akhteruzzaman Molla; Debra Montgomery; John K Pratt; Todd W Rockway; Rong Zhang; Dale J Kempf

doi:10.1016/j.bmcl.2006.04.015

Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-alkyl-4-hydroxyquinolon-3-yl-benzothiadiazine sulfamides

Bioorg Med Chem Lett. 2006 Jul 1;16(13):3367-70. doi: 10.1016/j.bmcl.2006.04.015. Epub 2006 May 2.

Authors

A Chris Krueger¹, Darold L Madigan, Wen W Jiang, Warren M Kati, Dachun Liu, Yaya Liu, Clarence J Maring, Sherie Masse, Keith F McDaniel, Tim Middleton, Hongmei Mo, Akhteruzzaman Molla, Debra Montgomery, John K Pratt, Todd W Rockway, Rong Zhang, Dale J Kempf

Affiliation

¹ Infectious Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA. [email protected]

PMID: 16650764
DOI: 10.1016/j.bmcl.2006.04.015

Abstract

Substituted N-alkyl-4-hydroxyquinolon-3-yl-benzothiadiazine sulfamides were investigated as inhibitors of genotype 1 HCV polymerase. Structure-activity relationship patterns for this class of compounds are discussed.

MeSH terms

Benzothiadiazines* / chemical synthesis
Benzothiadiazines* / chemistry
Benzothiadiazines* / pharmacology
Drug Evaluation, Preclinical
Enzyme Inhibitors* / chemical synthesis
Enzyme Inhibitors* / chemistry
Enzyme Inhibitors* / pharmacology
Molecular Structure
Structure-Activity Relationship
Sulfonamides* / chemical synthesis
Sulfonamides* / chemistry
Sulfonamides* / pharmacology
Viral Nonstructural Proteins / antagonists & inhibitors*
Viral Nonstructural Proteins / chemistry

Substances

Benzothiadiazines
Enzyme Inhibitors
Sulfonamides
Viral Nonstructural Proteins
NS-5 protein, hepatitis C virus