Hydrodynamic narrowing of tubes extruded from cells

Proc Natl Acad Sci U S A. 2006 May 16;103(20):7660-3. doi: 10.1073/pnas.0602012103. Epub 2006 May 5.

Abstract

We discuss the pulling force f required to extrude a lipid tube from a living cell as a function of the extrusion velocity L. The main feature is membrane friction on the cytoskeleton. As recently observed for neutrophils, the tether force exhibits a "shear thinning" response over a large range of pulling velocities, which was previously interpreted by assuming viscoelastic flows of the sliding membrane. Here, we propose an alternative explanation based on purely Newtonian flow: The diameter of the tether decreases concomitantly with the increase of the membrane tension in the lipid tube. The pulling force is found to vary as L(1/3), which is consistent with reported experimental data for various types of cells.

MeSH terms

  • Biophysical Phenomena
  • Biophysics
  • Cell Membrane / chemistry*
  • Cytoskeleton / metabolism*
  • Elasticity*
  • Mathematics
  • Membrane Fluidity
  • Membrane Lipids / chemistry
  • Micromanipulation
  • Models, Biological*
  • Stress, Mechanical*
  • Surface Tension
  • Thermodynamics
  • Viscosity

Substances

  • Membrane Lipids