Abstract
Bone marrow angiogenesis is increased in myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML), but has not been studied in inherited or acquired marrow failure syndromes. Shwachman-Diamond syndrome (SDS) carries a high risk of MDS/AML and is characterised by marrow stromal dysfunction. Compared with controls, SDS patients without MDS/AML had higher marrow microvessel density. Stromal VEGF gene expression, stromal vascular endothelial growth factor (VEGF) secretion and VEGF levels in serum and marrow mononuclear cells were normal. Future studies should investigate the mechanism for increased angiogenesis in SDS, and whether SDS marrow, with its increased angiogenesis, promotes progression of malignant clones.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Abnormalities, Multiple / genetics*
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Abnormalities, Multiple / pathology
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Acute Disease
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Adolescent
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Anemia, Aplastic / genetics
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Anemia, Aplastic / pathology
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Bone Marrow / blood supply*
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Bone Marrow / pathology
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Bone Marrow Cells / pathology
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Child
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Child, Preschool
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Female
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Gene Expression / genetics
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Hematologic Diseases / genetics*
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Hematologic Diseases / pathology
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Humans
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Infant
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Leukemia, Myeloid / genetics
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Leukemia, Myeloid / pathology
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Male
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Myelodysplastic Syndromes / genetics
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Myelodysplastic Syndromes / pathology
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Neovascularization, Pathologic / genetics
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Syndrome
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Vascular Endothelial Growth Factor A / genetics
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Vascular Endothelial Growth Factor A / metabolism
Substances
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Vascular Endothelial Growth Factor A