Abstract
The syntheses of some 3-substituted-2-(4-methyl-1-piperazinyl)-4-phenylquinolines are reported. The title compounds were tested for their potential activities on 5-HT receptor subtypes and 5-HT uptake site; compounds 4b-d showed micromolar affinity for 5-HT3 and 5-HT uptake site.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Binding, Competitive / drug effects
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In Vitro Techniques
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Ligands
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Male
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Paroxetine
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Piperazines / chemical synthesis*
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Piperazines / pharmacology
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Piperidines / metabolism
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Quinolones / chemical synthesis*
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Quinolones / pharmacology
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Quipazine / analogs & derivatives*
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Quipazine / chemical synthesis
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Quipazine / pharmacology
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Rats
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Rats, Inbred Strains
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Serotonin / metabolism*
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Serotonin Antagonists*
Substances
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Ligands
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Piperazines
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Piperidines
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Quinolones
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Serotonin Antagonists
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Serotonin
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Paroxetine
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Quipazine